![]() ![]() Freemont AJ The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain // Rheumatology (Oxford). Human intervertebral disc cells promote nerve growth over substrata of human intervertebral disc aggrecan // Spine 2006 31: 1187-93.Ģ1. Johnson WE, Sivan S, Wright KT, Eisenstein SM, Maroudas A, Roberts S. Human intervertebral disc aggrecan inhibits nerve growth in vitro // Arthritis Rheum 2002 46: 2658-64.Ģ0. ![]() Johnson WE, Caterson B, Eisenstein SM, Hynds DL, Snow DM, Roberts S. Nerve growth factor expression and innervation of the painful intervertebral disc // J Pathol 2002 197: 286-92.ġ9. Freemont AJ, Watkins A, Le Maitre C et al. The pathogenesis of discogenic lowback pain // J Bone Joint Surg Br 2005 87: 62-7.ġ8. Peng B, Wu W, Hou S, Li P, Zhang C, Yang Y. (1997) Nerve ingrowth into diseased in tervertebral disc in chronic back pain // Lancet 350: 178-181.ġ6. Freemont AJ, Peacock TE, Goupille P et al. Clinical diagnosis for discogenic low back pain // JBiolSci. Yin-gang Zhang, Tuan-mao Guo, Xiong Guo, and Shi-xun Wu. (2000) Low back pain in relation tolumbar disc degeneration // Spine 25: 487-492.ġ4. Cassinelli EH, Kang JD (2000) Current understanding of lumbar disc degeneration // Oper Tech Orthop 10: 254-262.ġ3. (2007) The cell biology of intervertebraldisc aging and degeneration // Ageing Res Rev 6:247-261.ġ2. (2007) Matrix synthesis and degradation in human intervertebral disc degeneration // Biochem Soc Trans 35: 652-655.ġ0. Le Maitre CL, Pockert A, Buttle DJ et al. (2008) Pathophysiology of the human intervertebral disc // Int J Biochem Cell Biol 40: 837-842.ĩ. Intervertebral discs which cause low back painsecrete high levels of proinflammatory mediators // J Bone Joint Surg Br. ![]() Burke JG, Watson RW, McCormack D, Dowling FE, Walsh MG, Fitzpatrick JM. Advances in susceptibility genetics of intervertebral degenerative disc disease // Int J Biol Sci.2008 4:283-290.ħ. Sun ZM, Miao L Zhang YG, Ming L Association between the-1562 C/T polymorphism of matrix metal proteinase-9 gene and lumbar disc disease in the young adult population in North China // Connect Tissue Res. Features of intervertebral disc degeneration in rat’s aging process // J Zhejiang Univ Sci B. Zhang YG, Sun ZM, Liu JT, Wang SJ, Ren FL, Guo X. Molecular pathogenic factors in symptomatic disc degeneration // Spine J. Paesold G, Nerlich AG, Boos N (2007) Biological treatment strategies for disc degeneration: potentials and shortcomings // Eur Spine J 16: 447-468.ģ. (2004) Advances in gene therapy for intervertebral disc degeneration // Spine J 4: 341S-347S.Ģ. Chadderdon RC, Shimer AL, Gilbertson LG et al. Wisely knowing when it's just on the verge of outstaying its welcome, the album wraps up at around the 40 minute mark, which I think is about right, and with that the band too decided to call it a day I guess wearing a Digital Veil to the funeral would be appropriate.1. That's an odd mixup of styles and they aren't always able to hide the seams, but for the most part they are just about able to make work, crafting it into a hard-edged progressively-inclined album which will have at least some appeal to those who crave metal with progressive sensibilities but prefer to go low on the cheese. This technically-inclined metalcore swansong from The Human Abstract finds the band dabbling in influences from djent and, particularly where the clean vocals are concerned, early Muse (circa Origin of Symmetry). The band has been critically acclaimed for their technical proficiency and stage presence. Minette previous to the recording of Midheaven. ![]() Their album Midheaven was released on Augand featured a new guitarist in Andrew Tapley, who had replaced A.J. Nathan Ells joined the band before heading into the studio to record the band's debut full length release 'Nocturne”, which was published by Hopeless Records August 22, 2006. Soon after signing to Hopeless Records, THA replaced singer Nick Olaerts with Nathan Ells. The band recorded a couple of demos and played a number of regional gigs before signing with Hopeless Records in 2005. Minette formed The Human Abstract in 2004, adding drummer Brett Powell, bassist Kenny Arehart, and singer Nick Olaerts. Guitarist Dean Herrera and guitarist / keyboardist A.J. The Human Extract is a progressive metalcore band from Los Angeles, California. ![]()
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